itk inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T37604	ITK inhibitor
	Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine recept...
T11690	ITK inhibitor 2		JAK
	ITK inhibitor 2 is a interleukin-2-inducible T-cell kinase (ITK) inhibitor , with an IC50 of 2 nM.		JAK
T61854	ITK inhibitor 5
	ITK inhibitor 5 (compound 27) is a highly potent and selectively targeted inhibitor of ITK. It exhibits IC50 values of 5.6 nM and 25 nM for ITK and BTK respectively [1].
T63229	ITK inhibitor 6
	ITK inhibitor 6 is a selective and potent ITK inhibitor that acts on ITK (IC50: 4 nM), BTK (IC50: 133 nM), JAK3 (IC50: 320 nM), EGFR (IC50: 2360 nM), LCK (IC50: 155 nM). ITK inhibitor 6 inhibited the phosphorylation of P...
T72397	PARP11 inhibitor ITK7	ITK7
	PARP11 Inhibitor ITK7 (ITK7) is a potent, selective inhibitor of PARP11, demonstrating significant efficacy with an IC50 value of 14 nM. It is primarily utilized in research focused on cellular localization.
T17220	Vecabrutinib	SNS-062	Tyrosine Kinases , BTK
	Vecabrutinib (SNS-062) is a potent and noncovalent BTK and ITK inhibitor (Kd: 0.3 nM and 2.2 nM, respectively). Vecabrutinib displays an IC50 of 24 nM for ITK.		Tyrosine Kinases , BTK
T14692	BMX-IN-1	BMX kinase inhibitor	BTK
	BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 ...		BTK
T35569	CTA 056		Apoptosis
	CTA 056 is an interleukin-2 induced T cell kinase (ITK) inhibitor, inhibits the growth of MOLT-4 xenograft tumors in mice, induces apoptosis in Jurkat cells, and can be used in the study of autoimmune disorders and T cel...		Apoptosis
T4263	BAY 61-3606	Syk inhibitor IV	Apoptosis , Syk
	BAY 61-3606 (Syk inhibitor IV) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.		Apoptosis , Syk
T4391	Syk Inhibitor II dihydrochloride	Syk Inhibitor II (hydrochloride)	Others , Tyrosine Kinases , Syk , PKC , BTK
	Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet fun...		Others , Tyrosine Kinases , Syk , PKC , BTK
T16493	PF-06465469		Others
	PF-06465469 is a covalent ITK inhibitor(IC50: 2 nM).		Others
T27458	GSK-2250665A	GSK2250665,GSK-2250665,GSK 2250665A,GSK 2250665
	GSK-2250665A is a Itk inhibitor with pKi value of 9.2.
T31982	GNE-9822	GNE 9822
	GNE-9822 is a potent selective ITK inhibitor that shows favorable ADME properties in preclinical species.
T69246	J-31
	J-31 is an inactive conformation inhibitor of ITK.
T14674	BMS-509744		Others
	BMS-509744 is an inhibitor of ATP competitive Itk (IC50: 19 nM).		Others
T40294	ITK/TRKA-IN-1
	ITK/TRKA-IN-1 is a chemical compound that functions as a dual inhibitor of IL-2-inducible T-cell kinase (ITK) and tropomyosin receptor kinase A (TRKA). With an IC50 value of 1.0 nM, it effectively inhibits the activity o...
T16578	PRN694		Others
	PRN694 shows extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo. PRN694 is an irreversible, highly selective, and effective covalent interleukin-2-inducible...		Others
T62343	EGFR-IN-40
	EGFR-IN-40 (compound 3z) is a potent inhibitor of BTK (IC50: 1.2 nM), EGFR (IC50: 5.3 nM) and ITK (IC50: 46.1 nM).
T63810	BTK-IN-7
	BTK-IN-7 is a selective and potent BTK inhibitor with an IC50 value of 4.0 nM. BTK-IN-7 exhibits high selectivity at both the enzymatic (ITK>250-fold, EGFR>2500-fold) and cellular levels (ITK>227-fold, EGFR27-fold). BTK-...
T39129	BMS-986143
	BMS-986143, an orally active, reversible BTK inhibitor with an IC50 value of 0.26 nM, is designed for autoimmune disease research. Additionally, it targets TEC, BLK, BMX, TXK, FGR, YES1, and ITK, exhibiting IC50s of 3 nM...